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Prevalence of HCM studied in older Native Americans


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  • Prevalence of HCM studied in older Native Americans

    Copyright 2004 Heart Disease Weekly via NewsRx.com & NewsRx.net
    Heart Disease Weekly

    August 29, 2004

    The prevalence of hypertrophic cardiomyopathy has been studied in older
    Native Americans.

    According to published research from the United States, "Recognition of the
    frequency with which hypertrophic cardiomyopathy (HCM) occurs in the general
    population is critical to understanding its demographics and public health

    "However, few data are available for estimating HC prevalence in large
    populations of different age strata and ethnic or racial groups. The Strong
    Heart Study is a prospective, population-based epidemiologic survey of
    cardiovascular disease in residents of 13 geographically diverse American Indian

    "The study population was comprised of 3,501 subjects with echocardiograms
    performed in 1993 and 1995 to determine the prevalence of HCM in middle-aged and
    older adult populations," B.J. Maron and coinvestigators, Minneapolis Heart
    Institute Foundation, explained. "Evidence of the HCM phenotype was present in 8
    previously undiagnosed patients (0.23%; 2 of 1,000) based on a left ventricular
    (LV) wall thickness greater than or equal to15 mm and a nondilated cavity that
    was not associated with another cardiac disease and was sufficient to produce
    the magnitude of hypertrophy evident.

    "Ages were 51 to 77 years (mean 64 ± 9). Four subjects were men and 4 were
    women, with prevalences by gender of 0.3% (3 of 1,000) and 0.18% (1.8 of 1,000),
    respectively. Maximum LV thicknesses were 19 to 29 mm (mean 21 ± 3)."

    The authors continued, "Two subjects had mitral valve systolic anterior
    motion, which was sufficient to produce LV outflow obstruction at rest in I
    patient. Different electrocardiographic abnormalities were present in five

    "In conclusion," Maron and coworkers wrote, "clinically unrecognized HCM was
    present in 1:500 of an aging American Indian cohort. This prevalence was similar
    to that reported in other general populations comprised of younger subjects of
    other races, offering evidence that HC is a relatively common genetic disease
    with widespread occurrence within the United States."

    Maron and coauthors published their findings in American Journal of
    Cardiology (Prevalence of hypertrophic cardiomyopathy in a population-based
    sample of American Indians aged 51 to 77 years (The Strong Heart Study). Am J
    Cardiol, 2004;93(12):1510-1514).

    Additional information can be obtained by contacting B.J. Maron, Minneapolis
    Heart Institute Foundation, Hypertroph Cardiomyopathy Center, 920 E 28th St.,
    Suite 60, Minneapolis, MN 55407 USA.
    Knowledge is power ... Stay informed!
    YOU can make a difference - all you have to do is try!

    Dx age 12 current age 46 and counting!
    lost: 5 family members to HCM (SCD, Stroke, CHF)
    Others diagnosed living with HCM (or gene +) include - daughter, niece, nephew, cousin, sister and many many friends!
    Therapy - ICD (implanted 97, 01, 04 and 11, medication
    Currently not obstructed
    Complications - unnecessary pacemaker and stroke (unrelated to each other)