Utility of transgenic rabbits reviewed

The utility of transgenic rabbit models for the study of human disorders has
been reviewed.

"Until recently, transgenic rabbits were produced exclusively by pronuclear
microinjection which results in additive random insertional transgenesis;
however, progress in somatic cell cloning based on nuclear transfer will soon
make it possible to produce rabbits with modifications to specific genes by the
combination of homologous recombination and subsequent prescreening of nuclear
donor cells," scientists in Hungary explained.

"Transgenic rabbits have been found to be excellent animal models for
inherited and acquired human diseases including hypertrophic cardiomyopathy,
perturbed lipoprotein metabolism and atherosclerosis," noted Z. Bosze and
colleagues working at the Agricultural Biotechnology Center in Godollo.

"Transgenic rabbits have also proved to be suitable bioreactors for the
production of recombinant protein both on an experimental and a commercial
scale," the researchers concluded.

Bosze and coauthors published their findings in Transgenic Research (The
transgenic rabbit as model for human diseases and as a source of biologically
active recombinant proteins. Transgenic Res, 2003;12(5):541-553).

Additional information can be obtained by contacting Z. Bosze, Agricultural
Biotechnology Center, Department of Animal Biology, H-2101 Godollo, Hungary.

The publisher of the journal Transgenic Research can be contacted at: Kluwer
Academic Publishers, Van Godewijckstraat 30, 3311 Gz Dordrecht, the Netherlands.

The information in this article comes under the major subject areas of Animal
Models, Biotechnology, Cardiovascular Disease, Genetic Disorders and Proteomics.