If this is your first visit, be sure to check out the FAQ in HCMA Announcements. You may have to register before you can post: click the register link above to proceed. To start viewing messages, select the forum that you want to visit from the selection below. Your Participation in this message board is strictly voluntary. Information and comments on the message board do not necessarily reflect the feelings, opinions, or positions of the Hypertrophic Cardiomyopathy Association. At no time should participants to this board substitute information within for individual medical advice. The Hypertrophic Cardiomyopathy Association shall not be liable for any information provided herein. All participants in this board should conduct themselves in a professional and respectful manner. Failure to do so will result in suspension or termination. The moderators of the message board working with the HCMA will be responsible for notifying participants if they have violated the rules of conduct for the board. Moderators or HCMA staff may edit any post to ensure it conforms with the rules of the board or may delete it. This community is welcoming to all those with HCM we ask that you remember each user comes to the board with information and a point of view that may differ from that which you hold, respect is critical, please post respectfully. Thank you


No announcement yet.

Thanks Bugs!


About the Author


Lisa Salberg Find out more about Lisa Salberg
  • Filter
  • Time
  • Show
Clear All
new posts

  • Thanks Bugs!

    Utility of transgenic rabbits reviewed

    The utility of transgenic rabbit models for the study of human disorders has
    been reviewed.

    "Until recently, transgenic rabbits were produced exclusively by pronuclear
    microinjection which results in additive random insertional transgenesis;
    however, progress in somatic cell cloning based on nuclear transfer will soon
    make it possible to produce rabbits with modifications to specific genes by the
    combination of homologous recombination and subsequent prescreening of nuclear
    donor cells," scientists in Hungary explained.

    "Transgenic rabbits have been found to be excellent animal models for
    inherited and acquired human diseases including hypertrophic cardiomyopathy,
    perturbed lipoprotein metabolism and atherosclerosis," noted Z. Bosze and
    colleagues working at the Agricultural Biotechnology Center in Godollo.

    "Transgenic rabbits have also proved to be suitable bioreactors for the
    production of recombinant protein both on an experimental and a commercial
    scale," the researchers concluded.

    Bosze and coauthors published their findings in Transgenic Research (The
    transgenic rabbit as model for human diseases and as a source of biologically
    active recombinant proteins. Transgenic Res, 2003;12(5):541-553).

    Additional information can be obtained by contacting Z. Bosze, Agricultural
    Biotechnology Center, Department of Animal Biology, H-2101 Godollo, Hungary.

    The publisher of the journal Transgenic Research can be contacted at: Kluwer
    Academic Publishers, Van Godewijckstraat 30, 3311 Gz Dordrecht, the Netherlands.

    The information in this article comes under the major subject areas of Animal
    Models, Biotechnology, Cardiovascular Disease, Genetic Disorders and Proteomics.
    Knowledge is power ... Stay informed!
    YOU can make a difference - all you have to do is try!

    Dx age 12 current age 46 and counting!
    lost: 5 family members to HCM (SCD, Stroke, CHF)
    Others diagnosed living with HCM (or gene +) include - daughter, niece, nephew, cousin, sister and many many friends!
    Therapy - ICD (implanted 97, 01, 04 and 11, medication
    Currently not obstructed
    Complications - unnecessary pacemaker and stroke (unrelated to each other)