Copyright 2003 Cardiovascular Week via NewsRx.com and NewsRx.net
Cardiovascular Week

May 19, 2003

SECTION: EXPANDED REPORTING; Pg. 21

LENGTH: 392 words

HEADLINE: HYPERTROPHIC CARDIOMYOPATHY: Location of hypertrophy a factor
affecting right ventricular diastolic filling

BODY:
Location of the myocardial hypertrophy of the left ventricle is a significant
factor affecting the right ventricular diastolic filling in patient with
nonobstructive hypertrophic cardiomyopathy.

"We examined whether differences in the location of myocardial hypertrophy
influence the right ventricular diastolic function in patients with non-
obstructive hypertrophic cardiomyopathy using cineanglography.

"Biplane right ventriculography was performed in 34 subjects (normal=14,
asymmetric septal hypertrophy=9, apical hypertrophy=11) during cardiac
catheterization.

"In patients with asymmetric septal hypertrophy, compared with apical
hypertrophy and normal groups, the indices of the right ventricular diastolic
function including right ventricular peak filling rate and filling fraction of
rapid filling phase were lower and the time to peak filling rate was prolonged,"
scientists in Japan report.

"But in patients with apical hypertrophy, these indices were not
significantly different compared with normal. There were no differences in right
ventricular ejection fraction and cardiac index among the three groups," wrote
K. Komaki and colleagues, Tohoku University, Graduate School of Medicine.

The researchers concluded: "These data suggest that the location of the
myocardial hypertrophy of the left ventricle is a significant factor affecting
the right ventricular diastolic filling in non-obstructive hypertrophic
cardiomyopathy."

Komaki and colleagues published their study in Tohoku Journal of Experimental
Medicine (Varieties of right ventricular diastolic function in patients with
non-obstructive hypertrophic cardiomyopathy. Tohoku J Exp Med,
2003;199(1):49-57).

For additional information, contact K. Shirato, Tohoku University, Graduate
School of Medicine, Department Cardiovascular Med, Aoba Ku, 1-1 Seiryomachi,
Sendai, Miyagi 9808574, Japan.

The publisher's contact information for the Tohoku Journal of Experimental
Medicine is: Tohoku University Medical Press, School of Medicine, Sendai,
980-77, Japan.

The information in this article comes under the major subject areas of
Angiology, Cardiology and Neurology.

This article was prepared by Cardiovascular Week editors from staff and other
reports.

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LOAD-DATE: May 16, 2003