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anti-inflammatory and fluid retention

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cynthiaG Find out more about cynthiaG
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  • anti-inflammatory and fluid retention

    Has anyone taken these which have caused a lot of fluid retention, resulting in congestive heart failure? A question for a board member--is it possible for say, Vioxx or any other anti-inflammatory to cause so much fluid build up that it causes the heart to over compensate and result in congestive heart failure symptoms?
    \"It is not length of life, but depth of life.\"

    Ralph Waldo Emerson

  • #2
    hhmm

    Dear Cynthia,

    I don't know the answer to your question. Have you looked up Vioxx on google.com or searched for vioxx and "fluid retention"? You should find something if it is something people are talking about.

    good luck,

    S

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    • #3
      Cynthia, Vioxx will cause fluid retention. Also, it is not recommended for those people with poor kidney function, the potential is there for causing greater impairment of kidney function and retention of fluid. Anything that causes fluid retention will contribute to CHF symptoms. Hope this helps. Linda

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      • #4
        I have taken Vioxx for lower back pain and never experienced any fluid retention at all. As with all medications, it affects everyone differently. We should not make blanket statements that a medication does or does not have certain sideaffects.

        Bob
        Cleveland Myectomy Crew
        Member since November 2002

        \"Chance favors the prepared mind!\"

        Comment


        • #5
          Thanks Linda and Sarah for your responses. One of my doctors had mentioned that the Vioxx could be a factor(she said that anti-inflammatories can cause fluid build-up in some people).My CHF symptoms went away since this happened in November, however, I'm still on Furosemide every other day until I see a HCM specialist in Boston next month. I'm in the process of having to change health ins. plans and finding new doctors and that includes a new cardiologist. I haven't had any problems up until November and it happened just a few months after I had been on Vioxx and then high doses of Ibuprofen for tendonitis. I'll find out more when I go to Boston.
          \"It is not length of life, but depth of life.\"

          Ralph Waldo Emerson

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          • #6
            From the Merck website:

            Fluid retention, edema, and hypertension have been reported in some patients taking VIOXX. In clinical trials of VIOXX at daily doses of 25 mg in patients with rheumatoid arthritis the incidence of hypertension was twice as high in patients treated with VIOXX as compared to patients treated with naproxen 1000 mg daily. Clinical trials with VIOXX at daily doses of 12.5 and 25 mg in patients with osteoarthritis have shown effects on hypertension and edema similar to those observed with comparator NSAIDs; these occurred with an increased frequency with chronic use of VIOXX at daily doses of 50 mg. (See ADVERSE REACTIONS.) VIOXX should be used with caution, and should be introduced at the lowest recommended dose in patients with fluid retention, hypertension, or heart failure

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            • #7
              Sorry Bob, I should have said Vioxx can cause fluid retention in certain people. Linda

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              • #8
                technicality

                Dear Bob,

                Linda should have written "will cause ----in some people" to be 100% totally correct, but I think the last part was understood.

                We do make blanket statements about side effects because we have to--I think it is pretty commonly understood that not everyone gets every side effect.

                I know Linda didn't mean to say "everyone will get fluid retention" from Vioxx.

                However, word choice is very important and being clear is important. AGH!

                S

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                • #9
                  I have been on Vioxx for a couple months. Prior to that I was on Bextra and prior to that I was on Celebrex (spellings??). I have osteoarthristis in the knees. The changes from one drug to the other was more to see if one would decrease the pain level more than the previous. Not because of any complications I was having relating to the drugs. Prior to going on celebrex/bextra/vioxx I always had a minor high blood preasure problem. My blood preasure didn't change after starting the celebrex, but my doctor decided to put me on blood preasure medicine because of the long history of minor high blood preasure. Blood presure seems to be pretty good and I didn't notice any change after switching to Vioxx.

                  But everyone is different.

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                  • #10
                    Actually, I was started on Vioxx last June. IF and I underscore, IF this did in fact cause so much fluid retention and if this CONTRIBUTED to CHF, is still in question. I felt fine being on the Vioxx for osteoarthritis of my hand....it did wonders....no pain at all...but I had always in the back of my mind thought of possible side affects (fluid retention, etc. etc). I was thinking that maybe I should have a cortisone shot (although after reading another message here, I'm having second thought..have to discuss with my doctor). In any event, it may be sheer coincidence that this (CHF)happened for the first time shortly after being on Vioxx. I hadn't had any symptoms in over 20 yrs. since I had been diagnosed with HCM. thanks everyone for your responses!
                    \"It is not length of life, but depth of life.\"

                    Ralph Waldo Emerson

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                    • #11
                      Linda and Sarah,

                      No apologies are necessary here. I understand all of what you are saying Sarah BUT... If someone comes to this board looking for information concerning Vioxx or other meds, and we tell them, in this case, that there will be fluid retention, then they may refuse to try a medication that could help them and not cause them any side effects. All I am asking is that we be a bit more cautious as to how we advise people.

                      Bob
                      Cleveland Myectomy Crew
                      Member since November 2002

                      \"Chance favors the prepared mind!\"

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