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HCM and Vioxx

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  • HCM and Vioxx

    [HCM and Vioxx]

    Author: Cynthia (---.dialup.mindspring.com)

    Date: 12-03-02 10:43

    I'm not sure if my original message was posted...so here goes another....anyone out there taking Vioxx who has HCM? I'm taking it for osteoarthritis. To make a long story short, I have developed fluid....had bronchitis symptoms but am seeing my cardiologist this Friday for an echo to see if anything has changed since my previous one. I have read extensively about serious side affects from Vioxx and heart disease. thanks!

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    [Re: HCM and Vioxx]

    Author: Sarah B. Board Moderator (12.144.99.---)

    Date: 12-03-02 10:57

    Dear Cynthia,

    From yourlawyer.com:

    The popular and heavily advertised arthritis drugs Vioxx and Celebrex have been linked by researchers to an increase in the risk of blood clots, heart attacks and strokes.The study from the Cleveland Clinic appeared in the Journal of the American Medical Association and was based on an analysis of previous clinical trials. Celebrex and Vioxx are projected to produce U.S. sales greater than $6 billion this year.

    In a study of more than 8,000 patients that compared the COX-2 inhibitor rofecoxib (Vioxx) with the traditional NSAID naproxen, the risk of cardiovascular problems, including heart attack, chest pain related to heart disease, stroke, sudden death and blood clots, was more than two times higher in the rofecoxib group than in the naproxen group.

    Vioxx and Celebrex are classified as and known as COX-2 inhibitors, or coxibs. COX-2 inhibitors, like older drugs such as ibuprofen and naproxen, are nonsteroidal anti-inflammatory drugs, or NSAIDs. Older NSAIDs reduce inflammation by blocking an enzyme called COX-2, but they also block another enzyme called COX-1. This enzyme helps protect the lining of the stomach, so blocking COX-2 can cause stomach irritation. COX-2 inhibitors only block COX-2, leaving the stomach-protecting COX-1 alone.

    The annual rates of heart attack in both the Celebrex (celecoxib) and Vioxx (rofecoxib) studies were increased compared to a review of studies containing a total of more than 48,000 patients. In those studies, 0.52% of patients taking an inactive placebo pill had a heart attack each year. The annual rate of heart attack was 0.74% for patients taking rofecoxib and 0.80% for those taking celecoxib.

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    [Re: HCM and Vioxx]

    Author: Sarah B. Board Moderator (12.144.99.---)

    Date: 12-03-02 10:59

    C

    http://www.merck.com/product/usa/pi_.../vioxx_ppi.pdf

    Fluid in the lungs is a side effect but is listed under "rare."

    S

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    [Re: HCM and Vioxx]

    Author: Cynthia (---.dialup.mindspring.com)

    Date: 12-03-02 11:39

    Thanks, Sarah! Actually, I was on that website last night.....as I mentioned, my doctor took me off the Vioxx as of yesterday. I don't know if this is a factor in what is going on, but after reading about this, it will be my choice to stay off Vioxx completely!

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    [Re: HCM and Vioxx]

    Author: Sarah B. Board Moderator (12.144.99.---)

    Date: 12-03-02 11:52

    C

    That sounds like a smart move!!!!!

    S

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    [Re: HCM and Vioxx]

    Author: Steve (---.proxy.aol.com)

    Date: 12-04-02 07:20

    For what it's worth, I've been on it for two years and so far no problems. I've been conserned about the Vioxx and Coumidin and did try to get off it, but went back on due to pain.

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    [Re: HCM and Vioxx]

    Author: Bryan (---.bos.east.verizon.net)

    Date: 12-04-02 07:46

    When I was on Vioxx, I was immediatly taken off of it after a week due to rapid heart beat and extreme shortness of breath
    NOTE: This is a post from the previous forum message board.

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