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  • Another coq10 question

    I have decided to start on coq10 but there are so many brands out there I'm having a hard time deciding on which to use. Does anyone recommend a certain brand that they've tried that works or vice-versa.

    Oh and I know that there have been no conclusive tests regarding the use and benefits of coq10 but it's hard to deny all the research that is out there. So if anyone has a certain brand that they prefer over another please let me know. Thanks!

  • #2
    brand

    i buy whatever doesn't have any fake colors or other crud in it. you probably pay a little more, but if they took the trouble to make it preservative-free, color-free, they probably use quality ingredients.

    Comment


    • #3
      The best company to buy co E 10 is from Carlson labs. They are the most expensive but the best company to buy it from according to my Mom and Uncle who have spent over 30 years in the health food business

      Gary

      I hope this helps

      Comment


      • #4
        Here is what the PDR has to say about CoQ10:

        Coenzyme Q10

        Full Text:

        Coenzyme Q10 (CoQ10)

        TRADE NAMES
        Coenzyme Q10 (CoQ10) is available generically from numerous manufacturers. Branded products include Lynae CoQ10 (Boscogen), Natures Blend Coenzyme Q10 (National Vitamin Company) and Ultra CoQ10 (Twinlab).

        DESCRIPTION
        Coenzyme Q10 or CoQ10 belongs to a family of substances called ubiquinones. Ubiquinones, also known as coenzymes Q and mitoquinones, are lipophilic, water-insoluble substances involved in electron transport and energy production in mitochondria. The basic structure of ubiquinones consists of a benzoquinone "head" and a terpinoid "tail." The "head" structure participates in the redox activity of the electron transport chain. The major difference among the various coenzymes Q is in the number of isoprenoid units (5-carbon structures) in the "tail." Coenzymes Q contain one to 12 isoprenoid units in the "tail"; 10 isoprenoid units are common in animals.

        Coenzymes Q occur in the majority of aerobic organisms, from bacteria to plants and animals. Two numbering systems exist for designation of the number of isoprenoid units in the terpinoid "tail": coenzyme Qn and coenzyme Q(x). N refers to the number of isoprenoid side chains, and x refers to the number of carbons in the terpinoid "tail" and can be any multiple of five. Thus, coenzyme Q10 refers to a coenzyme Q having 10 isoprenoid units in the "tail." Since each isoprenoid unit has five carbons, coenzyme Q10 can also be designated coenzyme Q(50). The structures of coenzymes Q are analogous to those of vitamin K2.

        Coenzyme Q10 is also known as Coenzyme Q(5O), CoQ10, CoQ(50), ubiquinone (50), ubiquinol— 10 and ubidecarerone. Chemically, CoQ10 is known as 2, 3-dimethyoxy-5-methyl-6-decaprenyl-1,4-benzoquinone, and its structural formula is:

        CoEnzyme Q10

        It is a solid wax-like substance. CoQ10 is the predominant form in humans, and CoQ9 is the predominant form in rats.

        Supplemental CoQ10 is typically derived from tobacco leaf extracts and fermented sugar cane and beets.

        ACTIONS AND PHARMACOLOGY
        ACTIONS
        Supplemental CoQ10 may have cardioprotective, cytoprotective and neuroprotective activities.

        MECHANISM OF ACTION
        Since the actions of supplemental CoQ10 have yet to be clarified, the mechanism of these actions is a matter of speculation. However, much is known about the biochemistry of CoQ10. CoQ10 is an essential cofactor in the mitochondrial electron transport chain, where it accepts electrons from complex I and II, an activity that is vital for the production of ATP.

        CoQ10 has antioxidant activity in mitochondria and cellular membranes, protecting against peroxidation of lipid membranes. It also inhibits the oxidation of LDL-cholesterol. LDL-cholesterol oxidation is believed to play a significant role in the pathogenesis of atherosclerosis.

        CoQ10 is biosynthesized in the body and shares a common synthetic pathway with cholesterol. CoQ10 levels decrease with aging in humans. Why this occurs is not known but may be due to decreased synthesis and/or increased lipid peroxidation which occurs with aging.

        PHARMACOKINETICS
        CoQ10 is absorbed from the small intestine into the lymphatics; from there it enters the blood. Absorption of CoQ10 is poor. Well over 60% of an oral dose is excreted in the feces. Furthermore, absorption of CoQ10 is highly variable and depends not only on food intake but also on the amount of lipids present in the food. Absorption is lower on an empty stomach and greater when taken with food of high lipid content. In the blood, CoQ10 is partitioned into the various lipoprotein particles, including VLDL, LDL and HDL.

        It takes about three weeks of daily dosing with CoQ10 to reach maximal serum concentrations, which then plateau with continuous daily dosing. CoQ10 is distributed to the various tissues of the body and is able to enter the brain. The main elimination of CoQ10 occurs via bile.

        INDICATIONS AND USAGE
        Coenzyme Q10 may be indicated in cardiovascular disease, particularly in congestive heart failure. It may also be indicated to correct reduced blood levels of CoQ10 that result from the use of HMG-CoA reductase inhibitors used to treat elevated cholesterol levels. It also appears to have usefulness in the management of periodontal disease in some. There is far less evidence to support claims that it has positive effects in cancer, muscular dystrophy and immune dysfunction. Similarly, there is as yet no reliable evidence that it can inhibit obesity or enhance athletic performance.

        RESEARCH SUMMARY
        There are many studies, spanning more than two decades, reporting positive results from the use of CoQ10 as adjunctive therapy in the treatment of congestive heart failure. CoQ10 has been an approved drug in Japan for use in congestive heart failure since 1974. It has also been approved for this use in some other countries. Several studies have demonstrated a strong correlation between severity of heart disease and severity of CoQ10 deficiency. Some have suggested that this deficiency is the primary cause of some variations of heart muscle dysfunction, while others believe it plays a secondary role in the etiology of heart failure.

        Early studies of congestive heart failure focused on idiopathic dilated cardiomyopathy, testing CoQ10 against placebo using echocardiography to assess heart function. Echocardiographic improvement seen in these studies was generally slow but sustained and was accompanied by diminished fatigue, chest pain, dyspnea and palpitations. Normal heart size and function were restored in some patients using only CoQ10; this occurred primarily in patients with recent onset of congestive heart failure.

        Subsequently, nearly all of the several placebo-controlled studies investigating CoQ10's effects on heart muscle function have reported significant positive results. One multi-center Italian study included 2,664 patients with congestive heart failure. No notable adverse effects on drug interactions have been reported in these studies except for one report that noted a slight diminution in coumadin activity.

        Many studies to date have examined CoQ10 as an addition to standard medical treatments. In several studies involving hypertension and other manifestations of cardiovascular disease, there was a significant reduction in the use of concomitant drug therapies when CoQ10 was added to the treatment regimen.

        It is now known that the HMG-CoA reductase inhibitors, while very effective in lowering cholesterol levels, also significantly lower levels of CoQ10. This may be particularly hazardous for patients with heart failure, suggesting a possible indication for CoQ10 in many, if not all, individuals using these cholesterol-lowering drugs. There has been some suggestion that CoQ10, especially if it could be more readily absorbed, might be a cholesterol-lowering agent itself. There is, however, no evidence for this.

        Significant CoQ10 deficiencies have been noted in diseased gingiva. CoQ10's efficacy in reducing gingival inflammation and periodontal pocket-depth has been demonstrated in placebo-controlled trials. Claims that CoQ10 might be an effective anti-cancer agent are based upon a few suggestive case histories that will require far more rigorous clinical investigation before these claims can be properly evaluated. Similarly, claims that CoQ10 might be useful in AIDS and some other immune dysfunctions are premature.

        It is not unreasonable to hypothesize that CoQ10 might be helpful in muscular dystrophy—and there is some very preliminary animal and clinical data suggesting that it might be. Muscular dystrophy is usually associated with cardiac disease. Research is ongoing but, to date, is inconclusive.

        There is also some evidence that CoQ10 might boost energy and speed recovery of exercise-related muscle exhaustion and damage. This work, too, needs more rigorous followup.

        There is no evidence that CoQ10 can inhibit obesity.

        CONTRAINDICATIONS, PRECAUTIONS, ADVERSE REACTIONS
        CONTRAINDICATIONS
        None known.

        WARNINGS AND PRECAUTIONS
        There is one report of CoQ10 decreasing the effectiveness of warfarin. Those taking warfarin should be aware of this possibility.

        Because of lack of long-term safety studies, pregnant women and nursing mothers should avoid CoQ10 supplements.

        Clinical reports from Japan suggest that supplemental CoQ10 may improve beta-cell function and glycemic control in type II diabetics. CoQ10 does not appear to improve glycemic control in type I diabetics. Diabetics should be made aware of this possibility, and those diabetics who do use supplemental CoQ10 should determine by appropriate monitoring if they need to make any adjustments in their diabetic medications.

        ADVERSE REACTIONS
        Mild gastrointestinal symptoms such as nausea, diarrhea and epigastric distress have been reported, particularly with higher doses (200 milligrams or more daily).

        INTERACTIONS
        DRUGS
        Warfarin: There is one report of CoQ10 decreasing the effectiveness of warfarin.

        Statins: CoQ10 and cholesterol share the same metabolic pathways. Inhibition of the enzyme 3-hydroxyl-3-methylglutonyl coenzyme A (HMG-CoA) reductase would be expected to decrease CoQ10 levels. The statin drugs lovastatin, simvastatin and pravastatin are known to decrease CoQ10 levels in humans. It is likely that all statins have this effect.

        Doxorubicin: CoQ10 may help ameliorate the cardiotoxicity of doxorubicin.

        Antidiabetic medications: CoQ10 may improve glycemic control in some type II diabetics. If this were to occur, antidiabetic medications might need appropriate adjusting.

        Beta Blockers: Some beta blockers, in particular propanolol, have been reported to inhibit some CoQ10-dependent enzymes

        Piperine: Piperine, found in black pepper, may increase plasma levels of CoQ10.

        DOSAGE AND ADMINISTRATION
        CoQ10 is available in different formulations: oil-based capsules, powder-filled capsules, and tablets and solubilized softgels (microemulsions and others). The solubilized softgels are claimed to give higher absorption.

        Daily doses of CoQ10 range from 5 to 300 milligrams. Those who use CoQ10 for periodontal health take 100 to 150 milligrams daily. Effectiveness, if any, is thought to be obtained with doses of 50 to 200 milligrams daily. The same dose range applies to those who take statin drugs for treatment of hypercholesterolemia.

        CoQ10 is best taken with food. About three weeks of daily dosing are necessary to reach maximal serum concentrations of CoQ10.

        CoQ10 is also available topically in some toothpastes and skin creams.

        HOW SUPPLIED
        Capsules — 10 mg, 30 mg, 50 mg, 75 mg, 100 mg, 150 mg

        Chewable Tablets — 100 mg, 200 mg

        Liquid — 30 mg/5 mL

        Powder

        Tablets — 25 mg, 50 mg, 60 mg, 200 mg

        Wafers — 60 mg, 200 mg

        LITERATURE
        Atar D, Mortensen SA, Flachs H, Herzog WR. Coenzyme Q10 protects ischemic myocardium in an open-chart swine model. Clin Investig. 1993; 71(Suppl):S103-S111.

        Baggio E, Gandini R, Plancher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. Mol Aspects Med. 1994; 15(Suppl):287-294.

        Bergossi AM, Grossi G, Fioletta PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquone reduction induced by HMG-CoA reductase inhibitors. Mol Aspects Med. 1994; 15(Suppl):187-193.

        Bliznakov EM, Wilkins DJ. Biochemical and clinical consequences of inhibiting coenzyme Q10 biosynthesis by lipid-lowering HMG-CoA reductase inhibitors (statins). Advanc Therap. 1998; 15:218-228.

        Chopra RK, Goldman R, Sinatra ST, Bhagavan HN. Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vitam Nutr Res. 1998; 68:109-113.

        Crane FL, Sun IL, Sun EE. The essential functions of coenzyme Q. Clin Investig. 1993; 71(Suppl):S55-S59.

        Folkers K, Mortensen SA, Littarru GP, Yamagami T, Lenaz G, eds. The biochemical and clinical aspects of coenzyme Q. Clin Investig. 1993; 71(Suppl):S51-S178.

        Folkers K. Critique of 30 years of research on hematopoietic and immunological activities of coenzyme Q10 and potentiality for therapy of AIDS and cancer. Med Chem Res. 1992; 2:48-60.

        Folkers K, Hanioka T, Xia L-J, et al. Coenzyme Q10 increase T4/T8 ratios of lymphocytes in ordinary subjects and relevance to patients having the AIDS related complex. Biochem Biophys Res Comm. 1991; 176:786-791.

        Folkers K, Langsjoen P, Willis R, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA. 1990; 87:8931-8934.

        Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the protective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Acad Sci USA. 1985; 82:901-904.

        Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10 -lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J Clin Pharmacol. 1993; 33:226-229.

        Hanioka T, Tanaka M, Oijima M, et al. Effect of topical application of coenzyme Q10 on adult periodontitis. Molec Aspects Med. 1994; 15 (suppl):S241-S248.

        Hanaki Y, Sugiyama S, Ozawa T, Ohno M. Coenzyme Q10 and coronary artery disease. Clin Investig. 1993; 71 (suppl):S112-S115.

        Henriksen JE, Andersen CB, Hother-Nielsen O, et al. Impact of ubiquinone (coenzyme Q10) treatment on glycaemic control, insulin requirement and well-being in patients with type 1 diabetes mellitus. Diabet Med. 1999; 16:312-318.

        Hofman-Bang C, Rehnqvist N, Swedberg K, et al. Coenzyme Q10 as an adjunctive in the treatment of chronic congestive heart failure. The Q10 study group. J Card Fail. 1995; 1: 101-107.

        Kishi H, Kishi T, Folkers K. Bioenergetics in clinical medicine. III. Inhibition of coenzyme Q10-enzymes by clinically used anti-hypertensive drugs. Res Commun Chem Pathol Pharmacol. 1975; 12:533-540.

        Kishi T, Watanabe T, Folkers K. Bioenergetics in clinical medicine XV. Inhibition of coenzyme Q10-enzymes by clinically used adrenergic blockers of beta-receptors. Rev Commun Chem Pathol Pharmacol. 1977; 17:157-164.

        Lampertico M, Comis S. Italian multicenter study on the efficacy and safety of coenzyme Q10 as adjuvant therapy in heart failure. Clin Investig. 1993; 71 (Suppl):S129-S133.

        Lass A, Sohal RS. Effect of coenzyme Q10 and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals. FASEB J. 2000; 14:87-94.

        Lucker PW, Werzelberger N, Hennings G, Rehn D. Pharmacokinetics of coenzyme ubidecarenone in healthy volunteers. In: Folkers K, Yamamura Y, eds. Biomedical and clinical aspects of coenzyme Q. Vol 4. Amsterdam: Elsevier Sci. Publ. BV. 1984; 143-148.

        Matthews RT, Yang L, Browne S, et al. Coenzyme Q10 administration increases mitochondrial concentrations and exerts neuroprotective effects. Proc Natl Acad Sci USA. 1998; 95:8892-8897.

        Morisco C, Trimarco B, Condorelli M. Effect of coenzyme Q10 therapy in patients with congestive heart failure: a long-term multi-center randomized study. Clinic Investig. 1993; 71(Suppl):S134-S136.

        Pozzi F, Longo A, Lazzarini C, Carenzi A. Formulations of ubidecarenone with improved bioavailabiltity. Eur J Pharm Biopharm. 1991; 37:243-246.

        Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet. 1994; 344:1372-1373..

        Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects human low-density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci USA. 1991; 88:1646-50.

        Tomasetti M, Littaru GP, Stocker R, Alleva R. Coenzyme Q10 enrichment decreases oxidative DNA damage in human lymphocytes. Free Rad Biol Med. 1999; 27:1027-1032.

        Tomono Y, Hasegawa J, Seki T, et al. Pharmacokinetic study of deuterium-labeled coenzyme Q10 in man. Int J Clin Pharmacol Ther Toxicol. 1986; 24:536-541.

        Watts GF, Castellucio CLA, Riceevans CLA, et al. Plasma coenzyme Q (ubiquinone) concentration in patients treated with simvastatin. J Clin Pathol. 1995; 46:1055-1057.

        Watts TLP. Coenzyme Q10 and periodontal treatment: is there any beneficial effect? Br Dent J. 1995; 178:209-213.
        "Some days you're the dog... some days you're the hydrant."

        Comment


        • #5
          Thanks for that info, Jim. From the PDR info, one thing that certainly stands out for those taking Coumadin (warfarin) is:

          "WARNINGS AND PRECAUTIONS
          There is one report of CoQ10 decreasing the effectiveness of warfarin. Those taking warfarin should be aware of this possibility."

          Just noting it for those who didn't look through all of the info since it is long.

          I don't have any personal experience with CoQ10 or different brands, so others can continue to address Darek's original question.-- Lisa Inman

          Comment


          • #6
            coQ10 brands

            The Vitaline brand is best. Many vitamins/supplements don't have much of what they say they do in them.

            http://www.allvita.net/coenzyme.htm

            Comment


            • #7
              agh

              ignore the link in my previous post. THIS company is the one that makes excellent supplements: http://www.phytopharmica.com/phytoPo...opDefault.aspx

              (i didn't realize "vitaline" wasn't the brand but a type)

              Comment


              • #8
                oh, yeah, and the large amount of vitamin E in the vitaline coQ10 will offset the affect coQ10 has on coumadin so it shouldn't throw you off.

                Comment


                • #9
                  Re: Another coq10 question

                  Originally posted by Darek View Post
                  I have decided to start on coq10 but there are so many brands out there I'm having a hard time deciding on which to use. Does anyone recommend a certain brand that they've tried that works or vice-versa.

                  Oh and I know that there have been no conclusive tests regarding the use and benefits of coq10 but it's hard to deny all the research that is out there. So if anyone has a certain brand that they prefer over another please let me know. Thanks!
                  The important thing to remember about CoQ10 is that the absorption is dependent on the form used. The best is the crystal-free variety. Ironically I am a Functional Medicine Consultant for a professional line nutrition company and have just been diagnosed with HCM. From the research I have done, it is possible for up to a 24% reduction in septal wall thickness by using at least 200mg of CoQ10 per day. I am launching on this grand experiment myself to see. If anything else, CoQ10 is vital for the proper function of the mytochondria in our cells and helps produce ATP, which is the fuel that keeps our cells churning. If you would like a more detailed discussion on CoQ10, you can click on a link on my personal website for a presentation that I train office staff with. Here is the link: http://timpateonline.com/ProHealthDo...m/CoQ%20NM.ppt

                  Comment


                  • #10
                    Re: Another coq10 question

                    I should look more closely at various brands, but whatever I'm taking, I'm pretty confident my 200mg a day has done me some good over the last few months. Who knew the statins could have such negative effects? If counteracting them is all my CoQ10 does, it's enough.

                    Joe

                    Comment


                    • #11
                      Re: Another coq10 question

                      Co Q 10 was a question that was asked of Dr. Lever in his webcast in January. He does not recommend this enzyme for his patients.
                      Onward and Upward !

                      Diagnosed 4/07 HCM with fixed & dynamic obstruction
                      Myectomy with resected cordonae tendonae 4/08 CCF
                      ICD 10/08

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