Advair Diskus 250/50

[Pam Alexson]

Well now that I caught up on all the posts, I have some questions. #1 Has any one taken Advair before ? #2 Has anyone had any problems with it? # 3 Is it contraindicated with HCM? #4 Has it helped?

I was given the first dose today at the pulmonologists office. He is aware of my problems and has seen me in the past. I was a little frightened when he sat back in his chair and put his finger over his lip,crossed his arms and said, "Hmmm let's see a septal myectomy?" I had to define it for him. Then he said, " Oh yes." Oh no just saying it I am scared . I probably should have vacated the premises at that moment Why do these things keep happening to me? Well soon after they gave me the Advair , I got chest pain and no I did not speak up. It went away fairly quickly, 2 minutes later and then everything seemed about usual for me.

Of course I have since read and found the cardiovascular effects and there are a few more then I like to see. As the next dose is due tonight , Please offer any input/ experience you may have with this med. I am supposed to use it for 2 weeks and am having repeat pulmonary funtiontests next week.
Thank you.
Pam

[shirleymahoney]

Re: Advair Diskus 250/50

Pam

I took 500 mg twice a day until they found out ididn't have asthma, they gave it to me in the hospital after surgery because they did not know what was wrong with me i just wasn't breathing well and i continued it until about a month ago, when my doc said discontinue it


As far as inneracting with your heart med it didn't with mine but, i was on a ccb and not a beta blocker i think there is something about taking it with taking beta blockers though i not sure though

Shirley

[sueb]

Re: Advair Diskus 250/50

I tried it and felt it made my back muscles hurt. Then, again, I tried it before I went out to work in the yard, which is something I don't often do.

Was on it for a week or so and didn't see anything adverse in terms of heart function.

I've gone back to albuterol when needed and Flovent (steriod) inhaler every morning and evening.

I don't take beta blockers either.

Is this enough paragraphs?

Sue

[SteveT]

Re: Advair Diskus 250/50

From the GlaxoSmithKline website, here is a quote from the prescribing document for doctors and pharmacists.

11. Cardiovascular Disorders: ADVAIR DISKUS, like all products containing sympathomimeticamines, should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension. Salmeterol, a component of ADVAIR DISKUS, can produce a clinically significant cardiovascular effect in some patients as measured by pulse rate, blood pressure, and/or symptoms. Although such effects are uncommon after administration of salmeterol at recommended doses, if they occur, the drug may need to be discontinued. In addition, beta-agonists have been reported to produce ECG changes, such as flattening of the T wave, prolongation of the QTc interval, and ST segment depression. The clinical significance of these findings is unknown.

It also mentioned that if you have a heart condition and take it that you should keep an eye on your potassium.

My advice though...talk to your pharmacist. They'll have the most reliable and up to date information.

Steve

[SteveT]

Re: Advair Diskus 250/50

I found this also.

Beta-Adrenergic Receptor Blocking Agents: Beta-blockers not only block the pulmonary effect of beta-agonists, such as salmeterol, a component of ADVAIR DISKUS, but may produce severe bronchospasm in patients with asthma. Therefore, patients with asthma should not normally be treated with beta-blockers. However, under certain circumstances, there may be no acceptable alternatives to the use of beta-adrenergic blocking agents in patients with 30 asthma. In this setting, cardioselective beta-blockers could be considered, although they should be administered with caution.

Sounds like you should talk to your pharmacist ASAP. The interaction may be minor, but better safe than sorry.

Steve

[Laoshur]

Re: Advair Diskus 250/50

Pam,
I have taken Advair 250/50 twice daily for about four years.

Yes, it helps my asthma. The downside is that beta blockers can cancel out its effects. This is why docs try to give beta blockers that are cardioselective - that is that have few effects in the lungs and bronchial tubes. The other side to the coin is that salmeterol (the "50" part of the 250/50) is a long acting bronchodilator, so it has stimulant effects similar to fast acting bronchodilators like albuterol. Therefore, it can cause heart problems such as chest pain, palpitations, arrhythmias, and syncope.

I have not noticed any problems with Advair, but when I used albuterol last winter, I had fairly severe chest pain that lasted about 30 minutes. So, do I think that Advair could cause your pain? Absolutely. Call your doctor before you take more.

Rhoda

[Pam Alexson]

Re: Advair Diskus 250/50

Thanks all for the good advise.
I am calling my pharmacist presently and will call my doctor also. Interesting I have never had asthma just treated for it and it was always found to be probably asthma, bronchitis, pneumonia, or CHF. Except this last spring it was "bronchitis", the effects have persisted intermittently in severity, like a chronic bronchitis.

Interesting is that long before my HCM diagnosis I was always having problems with excessive phlegm and mucus. I always aggravate my family trying to clear my trachea. They have always had to bang on my back to help me. It is so annoying.

I think he is looking at COPD and said he needs to do the PFT's to rule out some problems, of course I have severe sleep apnea as well and use Bi-pap machine.

I do have a specaled smoking history but none for 10 years and I had heavy exposure ;10 years to fomaldehyde and bleach . Both were heavily used in the disenfecting process treating dialysis patients and the artificial kidneys. I used to wonder if that would come back to bite me someday. We will see.
Take care and thanks.
Pam

[shirleymahoney]

Re: Advair Diskus 250/50

Pam

I feel for you that is what i was told too for years and i just had a feeling they were wrong when all the meds made me sick that they gave me for asthma and finally this doctor puts me in the hospital, because all the problems i was having pointed to the fact i did not have asthma, the meds would make me very sick and give me bad headaches

But it turned out that it was my heart, i mean my PCP said ......Look man i did a bnp and that showed him it wasn't my lungs causing my problems it was definetly my heart

Shirley

[Pam Alexson]

Re: Advair Diskus 250/50

Shirley ,
Thanks for your response. I'm going to hope that i am only mildly obstructed as he thought several years ago. I am not going to use the Advair until I talk w/ Dr. Maron . The pharmacist said after hearing my meds that my cardiologist needed to give me the go ahead . Bloop.... I should have thought of being more reactive when he didn't know what a septal myectomy was
Pam